Isaias Colon, Angelique Wise, Jenifer Prosperi

Sensitization of APC knock-out cells to Doxorubicin in vitro using KU55933, an ATM inhibitor

Biomedical

Background and Hypothesis: Triple negative breast cancer (TNBC) has the lowest 5-year survival rate among breast cancer subtypes, with Adenomatous P...

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Anslyn Freije, Melissa Abt, Tinslee Dilday, Elizabeth Yeh

Validation of Rubicon's Autophagy Inhibition Function Through HUNK Phosphorylation

Biomedical

Background and Hypothesis: HER2+ breast cancer uses the human epidermal growth receptor 2 (HER2) protein to grow. As an aggressive form of breast canc...

Review:

This abstract presents a compelling hypothesis regarding the role of HUNK phosphorylation in regulating Rubicon's autophagy inhibition function, parti...

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Kyle Richardson, Anika Shimonty, Joshua Huot, Fabrizio Pin, Lynda F. Bonewald

Sex-Dependent Effects of Irisin on Bone in an Aged Mouse Model

Biomedical

Irisin is a recently discovered protein that has garnered increasing attention due to its potential impact on metabolic health and disease prevention....

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Lillian Hatton, Elliot Androphy, Anne Rietz

Spatial Transcriptomics Demonstrates Tissue-Specific Differential Gene Expression in a Mouse Model of Spinal Muscular Atrophy

Biomedical

Background: Spinal muscular atrophy (SMA) is an autosomal recessive disease resulting from insufficient survival motor neuron (SMN) protein that affli...

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Alyssa Walker, Emily Seiden, Piper Wilburn, Ed Greenfield

Long Term Effects of Transient Romidepsin Exposure on Osteosarcoma Sarcospheres

Biomedical

Background:Osteosarcoma, the most prevalent primary bone cancer, disproportionally affects adolescents and young adults. Despite aggressive chemothera...

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Alexandra Cranston, Abigail Hall, Anushri Umesh, Nathan J. Alves

Exploring the Impact of Plasmin Inhibitors on Clotting Characteristics as a Novel Therapeutic for Thromboembolic Events

Biomedical

Background:Thromboembolisms are common, life-threatening emergencies. Systemic hemorrhaging post-thrombolytic treatment is an adverse reaction, highli...

Review:

This study introduces a compelling and potentially safer approach to treating thromboembolic events by investigating the co-delivery of plasmin and it...

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Joseph M. Dalloul, Devon Harvey, Jiannong Dai, Chenna Kesavulu Sugali, Weiming Mao

The Role of Cross-linked Actin Networks in the Proliferation and Senescence of Primary Human Trabecular Meshwork Cells

Biomedical

Purpose: TGFβ2 has been found to be elevated in the trabecular meshwork (TM) of patients with primary open-angle glaucoma. TM cells treated with TGFβ2...

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Sofiane Cherif, Abdelhafid Kaddour, Abdelmoudjib Benkada, Said Karoui

Detection of Laryngeal Pathologies from Voice using EMD-based Mel-Spectrograms and Scalograms with AlexNet

Biomedical

In this paper, a novel method for detecting of laryngeal pathologies using deep neural networks and time–frequency signal processing techni...

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Sridevi Rajalingam, Kavitha Maruthai

TRI-BCC: Tri-Level Breast Cancer Classification via Transfer Learning Networks with Histopathogical Images

Biomedical

Breast cancer (BC) is the second most common hereditary cancer in women and is most likely to affect women. The high cost of treating BC ha...

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Mahalakshmi S, Valarmathi K

AD-HOLDER: Alzheimer's Disease Detection via Machine Learning based Histograms of Light GBM Classifier using MRI and PET Images

Biomedical

Alzheimer's disease (AD) is an irreversible brain condition that impairs memory and cognitive processes. However, existing Alzheimer detect...

Review:

The paper "AD-HOLDER: Alzheimer's Disease Detection via Machine Learning based Histograms of Light GBM Classifier using MRI and PET Images" introduces...

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