Anslyn Freije, Melissa Abt, Tinslee Dilday, Elizabeth Yeh

Validation of Rubicon's Autophagy Inhibition Function Through HUNK Phosphorylation

Biomedical

Background and Hypothesis: HER2+ breast cancer uses the human epidermal growth receptor 2 (HER2) protein to grow. As an aggressive form of breast canc...

Review:

This abstract presents a compelling hypothesis regarding the role of HUNK phosphorylation in regulating Rubicon's autophagy inhibition function, parti...

View Full Research

Kyle Richardson, Anika Shimonty, Joshua Huot, Fabrizio Pin, Lynda F. Bonewald

Sex-Dependent Effects of Irisin on Bone in an Aged Mouse Model

Biomedical

Irisin is a recently discovered protein that has garnered increasing attention due to its potential impact on metabolic health and disease prevention....

View Full Research

Elizabeth Roy, Victor Olafusi, Enaja Sambatur, Faezeh Aghajani, Moti Gulersen, Asma Khalil, Vincenzo Berghella, Hiba J. Mustafa

Late Antenatal Corticosteroid Treatment in Twin Pregnancies and Neonatal Outcomes: A Systematic Review and Meta-Analysis

Medicine

Objective: To examine the impact of administering late-preterm corticosteroids on neonatal outcomes in twin pregnancies.  Study Design: A systema...

Review:

This systematic review and meta-analysis addresses a clinically pertinent question regarding the efficacy and safety of late-preterm antenatal cortico...

View Full Research

Susie Kim, Mark Fox, Heidi Beldinger-Burnett

Implementation of Indiana’s Universal Blood Lead Testing Mandate: Interviews with Primary Care Practices in Michiana

Administration

Background: Disparities in lead exposure and social determinants of health – including housing, environmental conditions, and nutrition security – inf...

View Full Research

Nathan Fuchs, Hallel Paraiso, Hannah Huang, I-Chen Ivorine Yu

Analysis of Cerebral Small Vessel Changes in an APOE4 Knock-In AD Mouse Model

Neuroscience

Introduction:  Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the leading cause of dementia worldwide.  Recently appro...

Review:

This study addresses a highly relevant and timely topic in Alzheimer's disease research: the differential impact of APOE4 on cerebral small vessels. G...

View Full Research

Alison Blodgett, Jonathan Guerrero, Baraka Muvuka

Food Insecurity: An Upstream Social Determinant of 30-Day Congestive Heart Failure Readmissions

Health

Background:   Approximately 6.7 million Americans have congestive heart failure (CHF), costing the healthcare system over $30 billion annual...

Review:

This study tackles a highly pertinent issue in healthcare: the significant burden and cost associated with 30-day congestive heart failure (CHF) readm...

View Full Research

Lillian Hatton, Elliot Androphy, Anne Rietz

Spatial Transcriptomics Demonstrates Tissue-Specific Differential Gene Expression in a Mouse Model of Spinal Muscular Atrophy

Biomedical

Background: Spinal muscular atrophy (SMA) is an autosomal recessive disease resulting from insufficient survival motor neuron (SMN) protein that affli...

View Full Research

Mae Shu, Mohammed Ghazali, Hannah Davis, Rohan Maniar, Patrick Loehrer

Optimizing CT Surveillance for Thymic Epithelial Tumors Based on Recurrence Characteristics

Medicine

Background: Thymic epithelial tumors (TETs), including thymoma and thymic carcinoma, are rare malignancies originating from the thymus gland epitheliu...

Review:

This study tackles a critical clinical need by aiming to optimize post-operative surveillance strategies for thymic epithelial tumors (TETs), a rare g...

View Full Research

Angela Tang, Ho-Ching Yang, Yomna Takieldeen, Shannon Risacher, Andrew Saykin, Yu-Chien Wu

Relationship between Perivascular Space Burden, White Matter Hyperintensities, and Cognitive Function

Cognitive

Introduction: Perivascular space (PVS) is believed to be involved in clearing metabolic waste from the brain. PVS has been found to increase in size i...

View Full Research

Jiayu Tian, Ivonne Cabrera, Chukwuebuka Ojukwu, Nicholas Harrison

Derivation of a Multivariable Model to Assist Emergency Department Triage of Heart Failure Patients by Their Diuretic Treatment Needs

Medicine

Background: Emergency medicine physicians (EMP) treat 1 million patients with acute decompensated heart failure (ADHF) annually. After emergency depar...

Review:

This paper addresses a significant challenge in emergency medicine: accurately triaging patients with acute decompensated heart failure (ADHF) based o...

View Full Research