Articles | Sciaria - Science Aria

Elеna V. Kuzubova, Alexandra I. Radchenko, Andrey А. Manuylov, Ariana M. Korokina, Natalia V. Koroleva, Ivan A. Yakovlev, Arthur A. Isaev, Roman V. Deev, Mikhail V. Korokin

Assessment of physiological parameters in the application of a double adeno-associated virus 9 with a codon-optimized DYSF gene for limb girdle muscular dystrophy type R2

Biomedical

Introduction: Gene therapy for Myoshi myopathy is extremely relevant, as it may become the first pathogenetic treatment for dysferlinopathy. The aim o...

Review:

This study presents an important investigation into a gene therapy approach for limb girdle muscular dystrophy type R2 (LGMD R2), a form of dysferlino...

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Nadezhda V. Nesterova, Natalia D. Bunyatyan, Irina A. Samylina, Vladimir A. Evteev

Cardiotropic medicinal products of plant origin. Prospects for use in modern clinical practice

Medicine

Introduction: The aim of the research was to study the current state of use and improvement of the prospects for the using cardiological medicinal pro...

Review:

This review article, "Cardiotropic medicinal products of plant origin. Prospects for use in modern clinical practice," tackles a highly pertinent subj...

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Svetlana G. Dorofeeva, Eugenia N. Konoplya, Oksana V. Mansimova

Correction of protein and lipid spectra of erythrocyte membranes as a pathogenetic supplement to the therapy of coronary heart disease

Medicine

Introduction: Coronary heart disease is currently a pressing problem in the medical and scientific community. The hemic component, which is a disrupti...

Review:

This study presents an intriguing exploration into the adjunctive therapeutic benefits of Mexicor in managing coronary heart disease (CHD), with a spe...

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Nikita V. Kudryashov, Alexander A. Gorbunov, Sergey E. Mironov, Dmitriy A. Tikhonov, Andrey A. Nedorubov, Olga Yu. Arshinova, Maria A. Simukhina, Vera N. Busol, Vladimir P. Fisenko

The effect of acute swimming stress, corticosterone, dexamethasone, and fludrocortisone on anxiety-like behavior in mice

Neuroscience

Introduction: Acute swimming stress (ASS) exerts a biphasic effect on anxiety-like behavior (ALB) in mice, inducing an enhancement and a subsequent de...

Review:

This study presents an intriguing investigation into the complex, biphasic effects of acute swimming stress (ASS) on anxiety-like behavior (ALB) in mi...

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Ramiz M. Salimov, Natalia А. Sukhorukova, Georgy I. Kovalev

Comparison of CD-1 and ICR mouse strains for impulsivity in the enriched cross-maze test: Effects of atomoxetine

Neuroscience

Introduction: Attention deficit hyperactivity disorder (ADHD) in children and adults is a neuropsychiatric condition that is characterized by difficul...

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This study presents an intriguing initial exploration into characterizing impulsivity in CD-1 and ICR mouse strains using an enriched cross-maze test,...

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Ekaterina V. Melnikova, Marina A. Vodyakova, Nikita S. Pokrovsky, Vadim A. Merkulov

Orthogonal approach and critical quality attributes for gene and cell therapy products

Biomedical

Introduction: Gene and cell therapy (GCT) products are revolutionizing medicine because they are made up of unique biological components like genetic...

Review:

This manuscript addresses a critically important and timely topic: the quality control of gene and cell therapy (GCT) products. Given the inherent com...

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Sergey B. Fitilev, Alexander V. Vozzhaev, Irina I. Shkrebniova, Dmitry A. Klyuev, Anna O. Ovaeva, Darya K. Barsukova

Adherence to dual antiplatelet therapy among outpatients after acute myocardial infarction in primary care

Medicine

Introduction: The efficacy outcomes of dual antiplatelet therapy (DAPT) observed in randomized controlled trials are often not replicated in real-worl...

Review:

This study effectively addresses a critical issue in cardiovascular secondary prevention: suboptimal adherence to dual antiplatelet therapy (DAPT) fol...

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Maria О. Maltseva, Kristina I. Adzhienko, Raul I. Musaev, Alexander A. Spasov, Vahid A. Mamedov, Natalia A. Zhukova, Sevil V. Mamedova, Nalatalia V. Eliseeva, Karina R. Magomedova, Dmitriy V. Maltsev

Anxiolytic, antidepressant and analgesic activities of novel derivatives of 1-(3-phenylpyrrol-2-yl)-1,3-dihydro-2H-benzimidazol-2-one

Pharmacy

Introduction: Benzimidazole (1,3-benzodiazole) derivatives hold an important place in the field of medicinal chemistry, since they have a wide spectru...

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This study presents a thorough *in vivo* investigation into the anxiolytic, antidepressant, and analgesic activities of novel 1-(3-phenylpyrrol-2-yl)-...

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Ivan S. Koklin, Petr R. Lebedev, Alim A. Kochkarov, Oleg S. Gudyrev, Vladimir V. Gureev, Aleksandr A. Dolzhikov, Eduard I. Taran, Mikhail V. Korokin

Regulation of 11β-hydroxysteroid dehydrogenase isoforms – novel drug targets for osteoporosis therapy

Biomedical

Introduction: Osteoporosis is an significant medical and social public health problem in an aging or elderly society, the issue of pharmacological cor...

Review:

This review article proposes a compelling novel pharmacological strategy for the treatment of osteoporosis, a significant and growing public health co...

Review:

This study addresses a critical public health challenge, stunting in young children in Indonesia, by proposing and evaluating a novel combined interve...