Elizabeth Roy, Victor Olafusi, Enaja Sambatur, Faezeh Aghajani, Moti Gulersen, Asma Khalil, Vincenzo Berghella, Hiba J. Mustafa

Late Antenatal Corticosteroid Treatment in Twin Pregnancies and Neonatal Outcomes: A Systematic Review and Meta-Analysis

Medicine

Objective: To examine the impact of administering late-preterm corticosteroids on neonatal outcomes in twin pregnancies.  Study Design: A systema...

Review:

This systematic review and meta-analysis addresses a clinically pertinent question regarding the efficacy and safety of late-preterm antenatal cortico...

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Susie Kim, Mark Fox, Heidi Beldinger-Burnett

Implementation of Indiana’s Universal Blood Lead Testing Mandate: Interviews with Primary Care Practices in Michiana

Administration

Background: Disparities in lead exposure and social determinants of health – including housing, environmental conditions, and nutrition security – inf...

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Nathan Fuchs, Hallel Paraiso, Hannah Huang, I-Chen Ivorine Yu

Analysis of Cerebral Small Vessel Changes in an APOE4 Knock-In AD Mouse Model

Neuroscience

Introduction:  Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the leading cause of dementia worldwide.  Recently appro...

Review:

This study addresses a highly relevant and timely topic in Alzheimer's disease research: the differential impact of APOE4 on cerebral small vessels. G...

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Alison Blodgett, Jonathan Guerrero, Baraka Muvuka

Food Insecurity: An Upstream Social Determinant of 30-Day Congestive Heart Failure Readmissions

Health

Background:   Approximately 6.7 million Americans have congestive heart failure (CHF), costing the healthcare system over $30 billion annual...

Review:

This study tackles a highly pertinent issue in healthcare: the significant burden and cost associated with 30-day congestive heart failure (CHF) readm...

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Lillian Hatton, Elliot Androphy, Anne Rietz

Spatial Transcriptomics Demonstrates Tissue-Specific Differential Gene Expression in a Mouse Model of Spinal Muscular Atrophy

Biomedical

Background: Spinal muscular atrophy (SMA) is an autosomal recessive disease resulting from insufficient survival motor neuron (SMN) protein that affli...

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Mae Shu, Mohammed Ghazali, Hannah Davis, Rohan Maniar, Patrick Loehrer

Optimizing CT Surveillance for Thymic Epithelial Tumors Based on Recurrence Characteristics

Medicine

Background: Thymic epithelial tumors (TETs), including thymoma and thymic carcinoma, are rare malignancies originating from the thymus gland epitheliu...

Review:

This study tackles a critical clinical need by aiming to optimize post-operative surveillance strategies for thymic epithelial tumors (TETs), a rare g...

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Angela Tang, Ho-Ching Yang, Yomna Takieldeen, Shannon Risacher, Andrew Saykin, Yu-Chien Wu

Relationship between Perivascular Space Burden, White Matter Hyperintensities, and Cognitive Function

Cognitive

Introduction: Perivascular space (PVS) is believed to be involved in clearing metabolic waste from the brain. PVS has been found to increase in size i...

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Jiayu Tian, Ivonne Cabrera, Chukwuebuka Ojukwu, Nicholas Harrison

Derivation of a Multivariable Model to Assist Emergency Department Triage of Heart Failure Patients by Their Diuretic Treatment Needs

Medicine

Background: Emergency medicine physicians (EMP) treat 1 million patients with acute decompensated heart failure (ADHF) annually. After emergency depar...

Review:

This paper addresses a significant challenge in emergency medicine: accurately triaging patients with acute decompensated heart failure (ADHF) based o...

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Alyssa Walker, Emily Seiden, Piper Wilburn, Ed Greenfield

Long Term Effects of Transient Romidepsin Exposure on Osteosarcoma Sarcospheres

Biomedical

Background:Osteosarcoma, the most prevalent primary bone cancer, disproportionally affects adolescents and young adults. Despite aggressive chemothera...

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Alexandra Cranston, Abigail Hall, Anushri Umesh, Nathan J. Alves

Exploring the Impact of Plasmin Inhibitors on Clotting Characteristics as a Novel Therapeutic for Thromboembolic Events

Biomedical

Background:Thromboembolisms are common, life-threatening emergencies. Systemic hemorrhaging post-thrombolytic treatment is an adverse reaction, highli...

Review:

This study introduces a compelling and potentially safer approach to treating thromboembolic events by investigating the co-delivery of plasmin and it...

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