Esra Nur Yeşilkent, Hamid Ceylan

Propolis and its therapeutic potential on wound healing

Introduction

Propolis and its therapeutic potential on wound healing. Discover propolis's therapeutic potential for wound healing. Explore its antimicrobial, anti-inflammatory, and regenerative properties, and its role in cellular repair processes. Promising research.

Abstract

Propolis is a resinous mixture collected by honey bees from tree buds or other plant sources. Propolis compounds have been the focus of many studies due to their anti-microbial, anti-cancer, and antiinflammatory effects. In addition, propolis is also recognized to have regenerative properties. It has been found to regulate a number of cellular and molecular processes such as wound repair and regeneration, hemostasis, inflammation, cell proliferation, and tissue remodeling. Many in vivo studies on wound models show that propolis has beneficial roles in wound healing. These beneficial roles have also been confirmed by clinical research studies. However, more research is needed on the dose, side effects, and clinical efficacy of propolis on wounds. In conclusion, research with different experimental models is promising as a potential therapeutic strategy in wound healing.

Review

This review effectively highlights the promising therapeutic potential of propolis in wound healing, positioning it as a natural product with significant multi-faceted benefits. The abstract concisely introduces propolis as a bee-derived resin with recognized anti-microbial, anti-cancer, anti-inflammatory, and regenerative properties, which are all highly relevant to the complex process of wound repair. The authors clearly establish propolis's involvement in critical cellular and molecular mechanisms, including hemostasis, inflammation modulation, cell proliferation, and tissue remodeling, setting a strong foundation for its proposed efficacy in wound management. The strength of this work lies in its affirmation of propolis's beneficial roles, supported by a spectrum of research. The abstract notes that *in vivo* studies on various wound models have consistently demonstrated positive outcomes, providing robust preclinical evidence. Furthermore, the confirmation of these therapeutic effects through clinical research studies adds significant weight and translational relevance to the claims, indicating that propolis's potential extends beyond laboratory settings into practical patient care. The overarching conclusion that propolis is a "promising as a potential therapeutic strategy" is well-supported by the described experimental and clinical findings. Despite the strong positive outlook, the review appropriately identifies crucial areas requiring further investigation, which is vital for any prospective therapeutic agent. The abstract clearly states the need for more extensive research concerning the optimal dosage of propolis for various wound types, a critical factor for both efficacy and safety. Furthermore, a thorough understanding of potential side effects and more rigorous evaluation of its overall clinical efficacy are essential before widespread adoption. Addressing these limitations through future research will be key to solidifying propolis's role as a standardized and evidence-based therapeutic option in wound care.

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