Sri Pitaloka, Mia Audina, Saftia Aryzki, Noval

Pengaruh Na.CMC Terhadap Uji Stabilitas Sediaan Gel Ekstrak Etanol Bunga Rosella (Hibiscus Sabdariffa L.) Sebagai Anti Aging

Introduction

Pengaruh na.cmc terhadap uji stabilitas sediaan gel ekstrak etanol bunga rosella (hibiscus sabdariffa l.) sebagai anti aging. Pelajari pengaruh konsentrasi Na.CMC terhadap stabilitas sediaan gel ekstrak rosella (Hibiscus Sabdariffa L.) sebagai anti-aging. Uji organoleptis, pH, viskositas, dan daya sebar gel.

Abstract

Ekstrak etanol bunga rosella (hibiscus sabdariffa L.) memiliki aktivitas antioksidan sebagai radikal bebas yang dapat meredam dengan penuaan dini sebagai anti aging maka perlu dibuat sediaan farmasi salah satunya topikal yang berupa gel. Sediaan gel dibuat dengan variasi konsentrasi Na.CMC untuk mengatahui pengaruh Na.CMC terhadap uji stabilitas sediaan gel ekstrak etanol bunga rosella. Stabilitas gel akan rusak jika sistem campurannya terganggu oleh perubahan suhu, komposisi yang berlebihan atau adanya penambahan salah satu fase secara berlebihan. Tujuan penelitian untuk mengatahui pengaruh variasi konsentrasi Na.CMC terhadap hasil evaluasi dan uji stabilitas sediaan gel ekstrak bunga rosella (hibiscus sabdariffa L) sebagai anti aging. Metode penelitian ini menggunakan rancangan pre eksperimental design yakni dengan one shot case study. Gel diformulasikan dengan variasi konsentrasi Na.CMC yaitu 2,5%, 5%, 7,5%. Uji stabilitas menggunakan metode cycling test meliputi uji organoleptis, homogenitas, pH, daya lekat, daya sebar, viskositas dan sineresis. Hasil penelitian menunjukkan variasi konsentrasi Na.CMC pada formulasi I 2,5%, formulasi II 5% dan formulasi III 7,5% sesuai dengan spesifikasi terhadap evaluasi yang dilakukan pada formulasi I, II dan III uji organoleptis, homogenitas, pH, daya sebar, daya lekat, sineresis dan viskositas formulasi III. Hasil statistik menunjukkan nilai kurang dari 0,05 yang berati terdapat perbedaan signifikan terhadap pH, viskositas, daya sebar, daya lekat terhadap variasi konsentrasi Na.CMC.Kesimpulan tidak terdapat pengaruh evaluasi organoleptis, homogenitas, pH, daya sebar, daya lekat, sineresis dan viskositas pada formulasi III sesuai dengan spesifikasi sedangkan pada statitisik stabilitas tidak stabil sebelum dan sesudah.

Review

This paper investigates the influence of varying concentrations of Sodium Carboxymethyl Cellulose (Na.CMC) on the stability of a rosella extract gel, intended for anti-aging applications due to the extract's antioxidant properties. The topic is highly relevant, addressing the growing demand for natural product-based pharmaceuticals and the critical need to ensure their stability in topical formulations. By focusing on a key gelling agent like Na.CMC, the study aims to provide insights into optimizing the physical and chemical characteristics of such preparations, which is essential for product efficacy and shelf-life. The methodology described involves formulating gels with three different Na.CMC concentrations (2.5%, 5%, 7.5%) and subjecting them to a cycling test to assess stability. A comprehensive range of parameters including organoleptic properties, homogeneity, pH, spreadability, adhesiveness, viscosity, and syneresis were evaluated. While the approach to stability testing using a cycling method and multiple parameters is appropriate, the abstract presents a significant and confusing contradiction in its reported results and conclusion. It states that all three formulations (I, II, and III) met specifications for most evaluations, and specifically that formulation III met specifications for all tested parameters. However, it then concludes with the perplexing statement that "statistically, stability was unstable before and after," despite earlier noting significant differences in pH, viscosity, spreadability, and adhesiveness due to Na.CMC concentration. In light of the conflicting information, the abstract, in its current form, struggles to deliver a clear and actionable conclusion regarding the influence of Na.CMC on gel stability. While the objective and experimental design show promise, the ambiguity in reporting findings, particularly the simultaneous claims of meeting specifications and being statistically unstable, severely undermines the study's impact. For a future revision or full manuscript, it is imperative to reconcile these contradictory statements, provide a more coherent interpretation of the statistical results, and clearly articulate the definitive role of Na.CMC concentration on the stability profile of the rosella extract gel. This would significantly enhance the clarity, scientific rigor, and overall contribution of the research.

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